Cheikh N'Digel Lô is a Senegalese musician. He was born in the town of Bobo Dioulasso in Burkina Faso. Lô began playing drums and singing at an early age. He joined Orchestre Volta Jazz, an ensemble which played Cuban and Congolese pop songs as well as traditional Burkinabé music. Lô moved to Senegal in 1978, performing in several mbalax outfits. By 1985 Lô was playing guitar with numerous Côte d'Ivoire and French musicians, which lead him to record material in Paris in 1987. After his band dissolved, Lô remained in Paris as a session musician, whilst developing his own sound, described as a mix of mbalax with reggae and soukous influences. In 1995 Youssou N'Dour offered to produce Lô's debut album, Ne La Thiass.
Lô is a member of the Baye Fall, part of the Muslim Mouride sect. As such, he has dreadlocks, which is part of the sect's customs. The reggae influence in his music, along with his dreadlocks, often leads to the misinterpretation that he is Rastafarian.
In 2002, he appeared on two tracks of the Red Hot Organization's tribute album to Fela Kuti, Red Hot and Riot. He collaborated with Les Nubians and Manu Dibango on one of the tracks, "Shakara / Lady (Part Two)."